Towards a More Sustainable Photocatalyzed α‐Arylation of Amines: Green Solvents, Catalyst Recycling and Low Loading

A more sustainable and efficient protocol for the photocatalytic α-amino arylation promoted by fac-Ir(ppy)3 was developed. Three noteworthy results were achieved: i) replacement of toxic medium DMA with greener solvents NBP NHP, concurrent improvement process efficiency lowering both amine base amount; ii) development a recycling solvent NHP commercially available costly photocatalyst fac-Ir(ppy)3, achieving environmental economic benefits. This approach to recovery avoids very demanding catalyst structural modifications; iii) in green proved be scalable up 10 mmol limiting reagent, maintaining excellent performance also loading down 0.05 mol%. is first example α-arylation amines such low amount catalyst. Lastly, versatility this demonstrated extending use another photoredox process.